Tuesday, September 19, 2023

PROCLAMATION: 9/27 Is World Dense Breast Tissue Day

9/19/2023- Mr. Joe Cappello, co-founder of the "Are You Dense?" Foundation was invited to attend the Santa Clara County Board of Supervisors meeting at County Government Center to receive an official proclamation by Santa Clara County Supervisor (and former California State Senator) JOE SIMITIAN, officially confirming September 27 as World Dense Breast Tissue Day. According to Mr. Simitian, this proclamation was sparked by earlier discussions about the late Nancy Cappello who passed away of breast-cancer related complications from dense breast tissue. "(Nancy's) own life experience... said others should have more power, more knowledge, more ability to affect the decision making in their own healthcare. For this, we are a better state, a better county, and in fact a better nation by virtue of her work."

To date, Joe Cappello continues to build and promote educational programs supporting research, clinical upgrades and improved scanning/monitoring programs. The "Are You Dense?" Foundation and "Are You Dense?" Advocacy are produced by the Cappellos in pursuit of saving lives through awareness through uniting with community leaders, clinical professionals and public recognition off the continued risks of having dense breast tissue.

TRANSCRIPT OF PROCLAMATION: 9/19/2023- County of Santa Clara Board of Supervisors

SPEAKER: Santa Clara County (CA) Supervisor Joe Simitian- District 5

Thank you, Madam President. And I'm going to look to the clerk to see if we can bring Mr. Joe Cappello from “Are You Dense?” in Connecticut up on the screen. I'll ask for a moment of patience, colleagues.

Colleagues and members of the public, you'll recall of course that just last week, we adjourned our meeting in memory of Nancy Cappello, who passed away almost five years ago now. And it provided an opportunity for our board to reflect on Nancy's extraordinary work over literally decades. We also took the opportunity at our last meeting to express our formal support for the Find It Early Act which is an effort at the national level congressional level to take the next step in terms of addressing the cancer risk of women with dense breast tissue. Today, we are calling out the formal acknowledgement of World Dense Breast Tissue Day. And the reason for that, Joe, and colleagues and members of the public is to ensure that we take advantage of this opportunity to identify September 27th as World Dense Breast Tissue Day, so that members of the public will have the information, the knowledge, the power that Nancy Cappello thought they were entitled to all those years ago.

And as we have discussed previously (so I won't speak at quite substantial length today) this is information that patients need to have. They are now entitled to have it by law. That entitlement is in large measure, a function of the fact that Nancy Cappello took her own life experience and said others should have more power, more knowledge, more ability to affect the decision making in their own healthcare. For this, we are a better state, a better county, and in fact a better nation by virtue of her work.

Joe, if you were here, I would have you up to the podium and I would hand you the physical commendation. But by virtue of our virtual connection today, I will virtually present it to you and we will send you the physical commendation and I hope it will find a place at “Are You Dense?”.

I'm guessing that your screen-? It doesn't reveal it, but I am wearing on my lapel the “Are You Dense?” button which I wore all those years ago when I was privileged to work with Nancy and the organization on California law. With that, Madam President, I say thank you to our board, and to my colleagues for their support on this measure and through the chair. With your permission, I'd like to give Mr. Cappello an opportunity to say a brief word or two.

Guest Speaker: JOE CAPPELLO
Well, thank you, Senator. As I said before, it's a real pleasure. I finally got to meet the other Joe in Nancy's life. And believe me, she always had kind words to say about you, and you were always a standup guy. You were the one that she could count on for honesty and truthfulness when we were doing our legislative work in California. What we have now is a disclosure law, which is a national law, which will take effect a year from now. This is huge step for the health of women all over this nation. What it's going to do is standardize (diagnostic care) in the medical field for women with dense breasts. I thank you in the name of Nancy for the proclamation. She deserves it all. She worked hard and worked smart. She was not only prettier than me, <laugh>, but smarter than me. And, I thank you on her behalf. I appreciate that. Thank you.

SPEAKER SIMITIAN:
Thank you, Joe Cappello. Thanks to "Are You Dense?" And thank you Madam President. We appreciate the work.

The Board of Supervisors of the County of Santa Clara, CA regularly meets in the Board of Supervisors’ Chambers, County Government Center, 70 West Hedding Street, San Jose. Regular meetings are held on designated Tuesdays at 9:30 a.m. The Board also holds regular meetings for the purpose of adjourning into Closed Session on Mondays at 2:00 p.m., which may be combined with meetings scheduled for the presentation of ceremonial items to be heard at 4:00 p.m.

Original airing: 10/2021

A NEED TO STANDARDIZE SCREENING WITH DENSE BREAST SCANNING

RUNNING THE TORCH OF A DENSE BREAST CANCER CHAMPION

Dr. Noelle Cutter drives the spirit of Dr. Nancy Cappello's mission for early cancer detection for women with dense breasts alongside Dr. Robert Bard's dense breast screening pilot program (8/27-29) - and the global pursuit to expand current screening standards.

What Does It Mean to Have Dense Breasts?

Source: CDC.gov

A mammogram shows how dense your breasts are. When you get the results of your mammogram, you may also be told if your breasts have low or high density. Women with dense breasts have a higher risk of getting breast cancer.

PARTS OF THE BREAST

A woman’s breast has three kinds of tissue: FIBROUS TISSUE holds the breast tissue in place. GLANDULAR TISSUE is the part of the breast that makes milk, called the lobes, and the tubes that carry milk to the nipple, called ducts. Together, fibrous and glandular tissue are called fibroglandular tissue. FATTY TISSUE fills the space between the fibrous tissue, lobes, and ducts. It gives the breasts their size and shape.

BREAST CANCER RISK: Women with dense breasts have a higher chance of getting breast cancer. The more dense your breasts are, the higher your risk. Scientists don’t know for sure why this is true. Breast cancer patients who have dense breasts are not more likely to die from breast cancer than patients with non-dense (fatty) breasts.

7/8/2021- A wave of recognized medical sites, journals and reports are now indicating that dense breast tissue increases the risk of developing breast cancer and often masks a tumor from being seen on the mammogram since dense tissue is white and cancerous tissue is also white. Mammograms are the standard screening test for breast cancer, however, in the 21st Century, ultrasound non invasive imaging is the preferred exam for dense “lumpy” mammary disease. The 1st World Conference of Breast Ultrasound in Philadelphia (1979) recognized ultrasound superiority in dense breast diagnostics but the density level was never quantified until recently. Mammography assessment of breast density is graded into four categories. Mammographers readily admit that these levels are subjective at best and technical factors such as mammary tissue compression and x-ray voltage/amperage dramatically influence the darkness or whiteness of the image.

URGENCY IN THE EVOLUTION OF TECHNOLOGY & IMAGING STRATEGIES FOR DENSE BREASTS

Written by: Dr. Robert L. Bard

Decades since the advent of breast scanning technology, innovations in non-invasive diagnostic imaging provide new options in the field of early detection. These technologies directly align with breast density screening (and are part of the Bard Breast Density Diagnostic Program) include:

• Doppler blood flow

• Contrast enhanced ultrasound vascularity

• 3D Vessel Density Histogram

• 4D Volumetric Density Histogram

• Strain and shear wave tissue Elastography

• 3T MRI

• Optical Computed Tomography (OCT) for nipple lesions

• Reflectance Confocal Microscopy (RCM) for dermal invasion

• Hybrid Mammo Imaging Fusion

• Thermo-sensor

• Trans Illumination

• Near Infrared Specroscopy

Hybrid imaging refers to combining diagnostic modalities to assess disease and monitor therapy. A useful combination of options is the tumor vessel flow density to assess aggression and treatment progress. Similarly, tissue elastography is useful for border detection of malignant masses.

FOR COMPLETE DETAILS ON THIS PROGRAM, VISIT: http://breastcancernyc.com/

Monday, September 18, 2023

Epigenetic Research Notes: Profiling the Dense Breast Paradigm

Written by: Dr. Roberta Kline.

As an Ob-Gyn physician and genomics specialist, I have spent the better part of 10 years translating research in the genomic and gene expression areas into clinically usable information for healthcare professionals. One of the biggest challenges we face when connecting research with patient care is the long delay in the translation process and dissemination of the information. It often takes 10 to 20 years for information (validated findings) that comes out of research to be applied in clinical practice. These delays result in many lost opportunities to provide better care for our patients. This is one of the reasons why I'm really passionate about accelerating this process and making it easier for clinicians and their patients to take advantage of cutting-edge information and new technologies.

LINKING DENSE BREAST WITH BREAST CANCER
We have known for a very long time that there is an increased risk of breast cancer for women who have dense breasts. Until recently, the research has been lagging in terms of what's the molecular mechanism, why do dense breasts present an increased risk of breast cancer? Without this knowledge, we can’t address the root causes, and are left with a lot of trial and error based on incomplete understanding.

It's very encouraging to know that currently there are 124 clinical trials ongoing looking at dense breasts and the relationship with breast cancer, anywhere from improved diagnostics, to treatment, to prevention, and, what’s close to my heart, to understanding the molecular mechanisms - what's happening at the cell level, at the genetic level that is causing different women to have an elevated risk of breast cancer.

One of the striking features that we're learning about dense breasts and what is creating that density is the microenvironment, which means the environment in the supporting tissue surrounding the glands. This includes fibroblasts and collagen. It seems that rather than estrogen being the dominant factor, it is inflammation that is creating the increased density of breast tissue.

ESTROGEN VS INFLAMMATION
What's fascinating to me is that even though we associate estrogen with the primary means by which women develop breast cancer, it may be a different process for breast cancers linked to breast density. Some of the research that has just come out in the last few years is showing us that rather than being hormonally driven, we think what's happening is there is an increase in these inflammatory markers in the tissue that is denser, and this is what can also lead to cancer.

There is clearly a genetic, or hereditary component, because having dense breasts is noted to run in families. But while having dense breasts increases a woman’s risk of breast cancer by up to 4-6x, not all of these women actually get cancer. That means there are other factors that can potentially increase as well as reduce a woman’s risk. This is where genomic research has been a gamechanger in identifying these other factors including for women with inherited genetic mutations, such as BRCA.

We now know that there are multiple genes in multiple other pathways that can modify a woman’s risk of breast cancer even if she carries a BRCA mutation. [1]. Researchers have identified smaller changes in genes called SNPs (single nucleotide polymorphisms) that have a much lower individual impact than genetic mutations, but together can be additive.[2] In fact, women with specific patterns of SNPs had their risk of breast cancer significantly reduced. This can help explain why not all women with BRCA mutations get cancer, and provides insight into potential protective biological mechanisms.

This is a really powerful paradigm shift, because now it opens the door for truly individualizing each woman’s risk – and potentially being able to change it through diet, lifestyle, or other modalities.

We now are also learning that gene SNPs can also play a role in a woman’s risk for dense breasts and breast cancer. While there's much research that needs to be done, from my experience, there's a lot we can do already to potentially intervene and help women with dense breasts. As we wait for more definitive research, we can learn from the nutritional genomics and functional medicine realms.

We have long known that pro-inflammatory conditions are underlying drivers for so many of the chronic diseases we see today, from cancer to heart disease, diabetes, autoimmune disease, depression and more. The flip side of inflammation is oxidative stress. They go hand in hand. Some of the genes that drive these processes are now also being linked to dense breasts and potentially the increased breast cancer risk that women with dense breasts have.

My question is, why can't we use some of these dietary lifestyle and nutritional supplement interventions that we already know decrease many of these pro-inflammatory pathways? Why can't we start using those in clinical practice as we wait for research and clinical trials to better refine our knowledge? The fact is, we can! But it takes education, awareness and advocacy to implement these strategies more widely and make a difference now.

Reference:

1) link to polygenic model – breast cancer, Lynch syndrome etc https://healthresourcedigest.blogspot.com/2022/03/the-future-in-personalized-medicine.html

2) Link to genetics/genomics https://modernhealing1.blogspot.com/2020/11/what-is-lynch-syndrome.html

The Latest: Advancement in Early Detection of Ovarian Cancer

According to the Society for Women's Health Research, Over 20,000 women will be diagnosed with ovarian cancer this year in the United States and women have a 92% chance of surviving for five years post-diagnosis. However, more than three-fourths of women are not diagnosed until later stages." [1] Abnormal ovaries are often benign simple cysts, however the complex cysts are classifiable with the new ultrasound scoring system as to how suspicious they may be. The same way we detect prostate tumors by routine yearly ultrasound screening in high risk patients, we could save many lives because sometimes the first sign of ovarian cancer is a gland in the neck that pops up, a mass under the arm or jaundice because the liver is filled with metastatic tumor.

EVOLUTION & INNOVATION IN DIAGNOSTICS

Written by: Dr. Robert L. Bard -excerpt from AngioResearch Journal(501c3)

Historically, the risk of ovarian cancer is linked to the current state of diagnostic technology. Though mortality rates have decreased over the years, cases of ovarian cancers may still reach critical stages when they are detected too late. This happens because early ovarian cancer is commonly hard to feel on a routine pelvic exam. In addition, by the time it spreads, it fills the abdominal cavity with metastatic fluid, making it difficult to palpate.

In 1980, I gave a talk for the American College of Obstetricians at Memorial Sloan Kettering Cancer Center where we presented the use of real-time imaging for the instantaneous documentation of the fetal heart beat by intrauterine cardiac sonogram to detect fetal demise instead of waiting 2 weeks to see if the fetus was growing. We asserted a similar use of ultrasound technology to monitor abnormal ovarian cysts as small as two centimeters (2-3 cm is about the size of a normal ovary). Early cancers could not be felt, but are imaged with ultrasound as the technology advanced. With today's high resolution and 3D imaging, (including endo probes with elastography for the uterus and ovaries) recent upgrades offer even better capabilities to conduct regular screening in real time called a noninvasive “virtual biopsy”.

In the 1990's, advancements in imaging allowed us to accurately detect prostate cancer, uterine cancer, and particularly see abnormal ovarian tumors. In addition, there is now an entire classification of ovarian cysts promoted by all the ultrasound and gynecologic societies to discern the fact that not all cysts are suspicious while some will be cancerous. Most of the ovarian cancers have cystic components. In my history as a practitioner, the first possible indicator of ovarian cancer was the swollen belly. Oftentimes, patients would come in after a CT for abdominal distension might show a fluid-filled abdomen, malignant ascitic fluid- and then when they drained the fluid, you might find an ovarian cancer tumor that metastasized to the lymph nodes, the mesentery membrane (the wall around the stomach area) or the liver.

Today's 3D imaging not only finds tumors that could be cancerous as small as 3cm, but we are also able to detect and look at suspicious lesions. While 3cm is considered sizable in the ultrasound field, it's not big in the gynecologic field because that's about the size of an average tumor. Ultrasound technology is now able to see three millimeter cancers in the glands, which we have been doing for the past 10 years

Instead of conducting biopsies on abnormal glands, we now employ the sonogram in areas like the axillary lymph nodes. If there is an abnormal gland with a tumor under ultrasound guidance we insert a tiny biopsy needle and aspirate cells for cytology, which are contemporaneously analyzed microscopically providing timely diagnosis and reduced patient anxiety from waiting and often avoids the risks of a full dissection of the axillary or groin lymph node.

Thanks to modern endo probes that can scan deeper organs, we study micrometastatic nodules throughout the body in superficial areas and in deeper areas like the ovary. The endo probes resolution is 5x greater than the MRI or the CT scanner. It is able to see not only the size and the irregularity in the cancerous wall of a cyst, but it measures the blood flow, which gives you a number of the abnormal tumor vessels in a cancer. Measuring the number of cancerous arteries indicates the severity of an ovarian tumor would be. Similarly, the fewer feeding blood vessels, the less malignant it is likely to be.

With our current 3D screening solutions, we now have a way to find cancers before they metastasized throughout the body. And we have the technology that can be used to study a cyst instead of doing a exploratory laparotomy to take out a suspicious ovary.

REFEERENCE

1) "Ovarian Cancer: Outdated Diagnostics for a Deadly Disease" Society for Women's Health Research- Feb 4, 2020. https://swhr.org/ovarian-cancer-outdated-diagnostics-for-a-deadly-disease/

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UNDERDIAGNOSED WOMEN & THE FALSE NEGATIVE

Over a decade after Gilda Radner’s passing in May of 1989, Dr. Nancy Cappello (a startlingly similar case of professional inefficiency and neglect) was diagnosed with stage 3C breast cancer in 2004 from a mis‐read mammogram, concealed behind dense breast tissue. A false negative mammography scan unidentified a large 2.5 cm suspicious lesion, which was later found via ultrasound readings was confirmed to be stage 3c breast cancer. This same cancer had metastasized to 13 lymph nodes. This sparked Dr. Cappello to create the "Are You Dense?" Foundation‐ an international awareness crusade to better support dense breast diagnostics and initiatives pass legislation to enact laws requiring mammography centers to inform patients about their breast density and the associated cancer risks.

Dr. Cappello passed away on Nov 15, 2018, from secondary myelodysplastic syndrome (MDS), a bone marrow cancer that was a complication of her prior aggressive breast cancer treatments. But she ignited a legacy of fighting for improved policies, advancing imaging technologies and continued research to better address this health crisis that puts the est. 40% of the female population (women with dense breasts) at risk of a false negative readings or other dense‐breast related cancers. The disorder or the cause may vary, but sad endings to stories like these remain common in our patient community. We stand at a major point in history when medicine offers the highest advancements in technological innovations and treatment options- if not for HUMAN ERROR, or the mis-management of those entrusted to give professional care. (See reprised feature from 10/2021 @: www.NYCRANEWS.com)

"ARE YOU DENSE?" MAKES SENSE IN DRIVING AWARENESS WEEK

By: Dr. Noelle Cutter

For most of America (or the many parents), September and the fall season means "Back to School and Back to work" from a summer of exhaustive and adventurous travels. But for another audience, the cancer awareness crusaders have a dedicated calendar for awareness months where the fall season may have the most cancers represented. According to the AACR (American Association for Cancer Research), the Fall calendar is comprised of a major set of public awareness programs promoted by dedicated cancer foundations. September's calendar alone has the following events for awareness months: Childhood Cancer, Leukemia and Lymphoma, Ovarian Cancer, Prostate Cancer, Thyroid Cancer and Uterine Cancer. Meanwhile BREAST CANCER AWARENESS MONTH stands in October as the top event.

Recent talks of a grassroots campaign to approach colleges about Dense Breast Awareness is in the works, according to Heidi Diaz, communications consultant for the "Are You Dense?" Foundation. Additionally, more clinicians are 'joining the fight' in support of the research including Dr. Roberta Kline (OB/GYN) who applauds the recent legislation in Congress to mandate clinical communication in Mammography centers about patients' tissue density. "This is the pathway to employing other imaging solutions like a supplemental ultrasound which clearly sees through dense tissue where mammography underperforms".

National Recognition in Dense Breast Research and Awareness

WOODBURY, Conn., Sept. 15, 2023 /PRNewswire/ -- Joseph Cappello, founder of the 'Are You Dense?' Foundation presented the first in a series of Cancer Research & Innovations awards to diagnostic imaging specialist Dr. Robert Bard (NYC). Since 1979, Dr. Bard's radiology practice spearheaded the use of ultrasound screening to complement scheduled mammograms for those with dense breast tissue. (It is noted that ultrasound scans are able to detect growths and tumors behind dense tissue, what mammograms tend to miss). At the time, no regulatory standard enforced the need for this 2nd scan, attributing to many undetected breast cancer tumors concealed by dense breast tissue.

Joseph Cappello, founder of the "Are You Dense?" Foundation honors cancer researcher & clinical diagnostic specialist Dr. Robert Bard (NYC) with the first Cancer Research & Innovations Award. This award recognizes clinical leadership in the advancement of early detection protocols and the improved screening of dense breast cases.

"Decades since the advent of breast scanning technology, a growing list of real-time innovations in non-invasive diagnostic imaging provide new options in the field of early detection", states Dr. Bard. "These technologies directly align with breast density screening that can easily complement a woman's regular mammogram. By updating the imaging process, we can safely combine diagnostic modalities and improve the assessment of disease and guide therapeutic procedures."

According to a 12/13/2022 press release, Congresswoman Rosa DeLauro (CT-03), Congressman Brian Fitzpatrick (PA-01), and award-winning journalist Katie Couric introduced their legislation, the Find It Early Act. This bill would ensure all health insurance plans cover screening and diagnostic mammograms and breast ultrasounds and MRIs with no cost-sharing. (See full news release)

"Dr. Bard will go down in medical history as one of the earliest change-makers in our crusade to improve women's early detection programs. His innovative approach to combine technologies makes him a true visionary for the next generation of cancer professionals... by standing his ground about the crisis and aiding in (what is now) a national legislation to save more lives!", states Mr. Cappello.

THE LEGACY OF DR. NANCY CAPPELLO

In 2014, Imaging Technology News (ITN) introduced breast cancer survivor-turned-crusader Dr. Nancy Cappello and her story about having dense breast tissue leading to a late-stage cancer. A false negative mammography scan (diagnosed in 2004) concealed a large 2.5 cm suspicious lesion, which was later confirmed to be stage 3c breast cancer. Dr. Cappello created the "Are You Dense?" Foundation to better support dense breast diagnostics and to pass legislation and laws requiring mammography centers to inform patients about their breast density and the associated cancer risks. Dr. Cappello passed away on Nov 15, 2018, from secondary myelodysplastic syndrome (MDS), a bone marrow cancer that was a complication of her prior aggressive breast cancer treatments. Her legacy continues to help address this health crisis that puts the est. 40% of the female population (women with dense breasts) at risk of a false negative readings.

Are You Dense, Inc. pursues the national mission to educate the public about the risks and screening challenges of dense breast tissue and its impact on missed, delayed and advanced stage breast cancer to reduce advanced disease and mortality.

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Saturday, September 16, 2023

The Next Phase of Battling Breast Cancer Cases

"ARE YOU DENSE?" MAKES SENSE IN DRIVING AWARENESS WEEK

By: Dr. Noelle Cutter

Recognizing the link between having Dense Breast tissue and the potential risk for Breast Cancer is what drives advocacy groups like the "Are You Dense?" Foundation. Prompting a national education project is a decades-old mission that cancer docs and patient advocates alike are in a constant search for action-plans. For the reasons why Breast Cancer continues to capture the heart of the battle within a national Awareness Month, the community now has DENSE BREAST AWARENESS WEEK as the last week if September to transition to Breast Cancer Month of October.

Recent talks of a grassroots campaign to approach colleges about Dense Breast Awareness is in the works, according to Heidi Diaz, communications consultant for the "Are You Dense?" Foundation. Additionally, more clinicians are 'joining the fight' in support of the research including Dr. Roberta Kline (OB/GYN) who applauds the recent legislation in Congress to mandate clinical communication in Mammography centers about patients' tissue density. "This is the pathway to employing other imaging solutions like a supplemental ultrasound which clearly sees through dense tissue where mammography underperforms".

National Recognition in Dense Breast Research and Awareness

"I learned that there are many women like me with recent normal mammogram reports with a hidden intruder stealing their life. I am on a quest to expose this best-kept secret of dense breast tissue to ensure that women with dense breast tissue receive screening and diagnostic measures to find cancer at its earliest stage - isn't that the purpose of Screening Programs?" - Dr. Nancy Cappello

Mr. Cappello personally presented the award with fellow executives Donna Johnson from Woodbury CT (Pres. of Are You Dense Foundation) and Marion Bradley from Beacon Falls, CT (Pres. of Are You Dense Advocacy Foundation) as a gesture of appreciation for Dr. Bard's clinical achievements.

Since 2019, Mr. Cappello's Are You Dense Advocacy Foundation succeeded in helping to pass National legislation to federally mandate breast screening centers to address the dense breast crisis with the ultrasound complement. Mr. Cappello's commitment to enforce this legislation nationally, started with his wife, the late Dr. Nancy M. Cappello who passed away due to complications with her late stage breast cancer treatment.

THE LEGACY OF DR. NANCY CAPPELLO

Monday, August 7, 2023

Spotlight: Dr. Donato Pérez García & IPT/Insulin Potentiation Therapy

The NY Cancer Resource Alliance is proud to honor the work of Dr. Donato Pérez García - leading global expert in IPT/IPTLD (Insulin Potentiation therapy)- a bioregenerative medical procedure. Dr. Donato has been practicing the IPT protocol since 1983 and is a current and active physician in Tijuana, Mexico. He is Certified in Regenerative Medicine and Stem Cell Therapy. He is also a Member, Advisor and Professor of the Medical College for Regenerative Medicine. He focused his research on the expansion of cancer treatment, arthritic conditions and an array of chronic illnesses since founded by two prior generations of his forefathers in the 50's.

WHAT IS IPT?
To define, insulin potentiation therapy is a bio regenerative medicine procedure that uses a dose of fast-acting insulin as a biological response modifier to induce cell permeability in a controlled manner and thus facilitating the exchange between extra and intracellular fluids. This allows drugs to enter the cell interior, going to the specific site to generate a chemical and physical change that contributes to repair cell function in most cases.

Dr. Donato often establishes the scientific background about disease only occurring within the cell. He explains that "a cell is the basic unit of the body. When one or more of the cellular components do not perform their physicochemical function, alterations are generated that give manifestations and that is a disease. Many chronic degenerative diseases like Respiratory diseases, Gastric diseases, Gastritis, Rheumatoid Arthritis, Lupus, Osteoporosis, Sarcoma, Hodgkin’s Lymphoma, ME, Chronic infections, Prostatitis, Colitis, as well as cancer, to treat them medically, it is necessary to enter the interior of the cell to carry out the physicochemical corrections that reverse the alterations of one or several cellular organelles and thus restore the state of health. For the treatment of many diseases, it is necessary to use an integrative program that includes nutrition and some complementary therapies to restore cell function or sometimes to prepare the body to receive stem cells.

Dr. Garcia dedicated his profession to the continuance of the work originally founded by his grandfather, Dr. Donato Pérez García Sr. (Right image-R) in the 1950's where his work was focused on treating bacterial and venerial disease in military personnel. IPT was significantly expanded by his father Donato Perez Garcia y Bellón (practiced from 1956 to 2000) in Mexico City, and vastly added to IPT education and clinical research. This led to the recorded success in treating an extensive array of cancers and infectious diseases and chronic conditions.

7/11/2023- In a private interview, Dr. Donato generously shared the evolution of this groundbreaking protocol through the applied research and continued patient success by his own findings and those from his forefathers. He approved this interview with the hopes of bringing awareness to IPT and "publishing positive facts that will help doctors understand the protocol so they can offer this to people who are interested a much more effective approach to treatment".

The medical world owes the three generations of Dr. Garcia's a debt of gratitude for their historical contributions of upending the effects of pre-existing therapeutic treatments. Today's vastly growing community of IPT clinicians across the globe continued to forge the likelihood of bringing so many more patients into remission.

INTERVIEW
By: Dr. Donato Pérez García

By now, most of the doctors that are familiar with insulin potentiation therapy are using this for treating malignant conditions such as cancer tumors. From my vast clinical experience in applying IPT to cancer patients, I would say the patients success rate with the insulin therapies after the patient's case has been reviewed and depending on the stage and treatments can be between 76 to 82%. Okay. That is compared to a lower number of success with the high dose of standard chemotherapy. As long as there are medications or chemical substances that can be effective, IPT is able to complement that treatment of a particular disease.

The term "Insulin Potentiation Therapy" was a name that was formed sometime in 1985- 86. It was an attempt at making the procedure easier to remember for the American Medical community and the medical doctors in the United States. But the original name that my grandfather gave it to his medical procedure (back in the 40's) was a much longer one- he called it "CELLULAR THERAPY THROUGH THE BIO PHYSICO CHEMICAL CONSTANTS OF THE BLOOD”.

Since 1930, he initially started to treat patients who had bacterial infection in the military. He was the head of the Army clinic where venereal or sexually transmitted diseases- specifically syphilis. By the mid-fifties, he also had a good idea of treating gastric and duodenal ulcers. He used the current available resources including sulfa, penicillin, and bismuth a substance that protects the gastrointestinal membrane and an anti-infective agent. Next came polio in the 1950's & 60's where children in Mexico grew heavily infected. My grandfather achieved great success by formulating a solution to reduce the replication of the virus. He injected insulin followed by a formula of medications inducing antiviral activity. By then, my father joined the practice alongside several lab chemists to help fortify these solutions.

Reports of their findings from a wide range of clinical studies were assembled into reports submitted to medical academies and then to the American Embassy. They also reached out to universities like Loyola and Houston, then MD Anderson Research Center to share their results as far as the effects and changes induced by the administration of insulin.

IPT TODAY
Little attention was given to my grandfather's and father's reports until the late 80's. The United States Congress created the Office of Complementary and Alternative Medicine and their chief investigator at the time (Dr. Maryanne Richardson) was in a global search for supportive solutions for cancer therapy. She learned about the IPT reports and findings and sought out Dr. Donato from Mexico. By this time, I took over the mantle that my grandfather and father started in the 60's and I met with Dr. Richardson and other agencies in support of establishing the next voice for Insulin Potentiation.

Currently, the Academy for IPT is under review because the American and European doctors are trying to formalize the platform. I joined the Academy of Regenerative Medicine and they are going to start offering courses on non-diabetic use of insulin potentiation therapy. I'll now be a teacher within that organization while managing to see patients in need of care. I would also be supporting the work of the Academy for IPT, also to continue the educational mission internationally.

I produced a major book project on IPT and is currently being reviewed by the educational department of the Academy for Regenerative Medicine. The presentation is an upgrade on the way insulin potentiation therapy was taught in the past. I was convinced by this academy to really do some good research and put the right name(s) with the right evidence in order to present a program that goes with the evidence-based medicine and backed by the science that will support this, so the new training program will be available by the end of September of 2023.

REFS

1) https://www.iptq.com/donato3.htm

2) Dr. Garcia's website: https://donatoperezgarcia.com/

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Sunday, July 2, 2023

SPOTLIGHT: DR. DAVID MINKOFF AND INSULIN POTENTIATION THERAPY

The NY Cancer Resource Alliance and the Integrative Pain Healers group spotlights the work of David Minkoff, M.D. co-founder of LifeWorks Wellness Center (Clearwater, FL)- recognized as one of the largest alternative medical clinics in the US. Dr. Minkoff has spent decades in the practicing in the areas of pediatrics, infectious disease and integrative medicine.

IPHA NEWS presents an exclusive report about an alternative cancer therapeutic protocol called IPT or INSULIN POTENTIATION THERAPY. IPT is widely applied and supported by some of the top integrative cancer treatment experts like Dr. Jesse Stoff (Onco-Immunologist). Dr. Minkoff has recorded significant success with this program and is underway the launch an expansion project to train other doctors on the science of IPT.

INTERVIEW
by: Dr. David Minkoff

The Wall Street Journal yesterday had an article about cancer doctors now looking at less extreme therapies, lower dose therapies for showing success in colon cancer. Now, we've known this forever, you know, you are killing people with your therapies. But yeah, I think we're having an impact on them and um, you know, I mean, ideally they would come to their senses if you had the, the shoulders of MD Anderson or Sloan behind, Hey, let's figure out what would be the optimum usage of chemo drugs for cancer. Why you could get a lot done in a short period of time that would help 10, you know, billions of people.

The basic mechanism of a cancer cell was figured out in the late 1920's to early 1930's. A German medical doctor named Dr. Otto Warburg made the observation that the metabolism of a cancer cell is different than the metabolism of a healthy cell- and that if you wanted to find one common denominator of cancer cells, it's that their metabolism is altered, such that the cell does not utilize oxygen in order to make energy. And because of that, the cell gets mostly dependent on glucose for its fuel and not on fatty acids or proteins.

CANCER SCANNING
Most people who get cancer get a PET scan. A PET scan gives the person an IV dose of a glucose molecule that has a radioactive tag so the scanner can pick up where it goes. Now, because it's a glucose molecule and the cancer cells are utilizing glucose more than a healthy cell (and they take up glucose way better than a healthy cell) if you do this scan, the areas where the cancer lights up on that scan will give you a pretty good estimation of how much more glucose are they taking up than the healthy cells. Hence, if the cancer is in the liver, the cells in the liver will take up more than the non cancer areas. The scan measures the glucose uptake per cell. It records it as SUV or sugar uptake value. A normal are is SUV 1. In the cancer areas it can go from 5 or 10 to even fifty. This is a reflection of the glucose uptake and thus the rate of metabolism of the cancer cell. An SUV of 5 means the rate of growth is 5x the normal cell. This proves that these cancer cells are utilizing glucose a lot as their main source of fuel.

A STRATEGY THAT SAVES MORE LIVES
The brilliance of DONATO GARCIA SR. was that you could trick the cancer cell into taking up things that weren't good for it if you were able to pair them with increased glucose. In order for glucose to get in a cell, it needs a door opener because there's a door where glucose goes in and that door needs a key. That key is INSULIN. In a healthy person, you eat some mashed potatoes (and) your blood sugar goes up. Insulin is released from your pancreas and it goes around the body and the bloodstream, then into the cells. It opens doors so that the blood sugar can go from your blood. So you eat the mashed potatoes and your blood sugar goes up, and the insulin is put into the blood stream and brings the sugar level back down. This is what normally happens all the time with eating. The way IPT works is that we actually give insulin to the fasting patient. This brings the blood sugar way down. This alone stresses the cancer cells as they are dependent on sugar being available. .

Meanwhile, your other cells can utilize fatty acids, proteins and amino acids for fuel. So the insulin also opens up all the doors on these cancer cells. If we have a healthy cell next to the cancer cell, it's got one glucose door and it opens. The cancer cell (let's say) has 10 extra insulin receptors and opens up 10 doors. Now you induce the chemotherapy or anti-cancer therapies- and this can be done in VERY LITTLE AMOUNTS because you're going to deliver multiples of 10, 20, 50 times the drug to the cell that's got the open glucose doors. Because the doors are open, the treatment is put into the bloodstream, a bit of glucose is given, which then these cells suck up all the treatment you're giving them more efficiently.

Hence, the cancer cells get a massive hit and your (healthy) regular cells get only a little hit. By a 'little hit', this means practically nothing-- so insignificant that nobody loses their hair. We watch very carefully what the dosage is so that their immune system doesn't go down. Our goal is to try to kill cancer cells while preserving the immune system. The problem with full dose chemo is that they're killing healthy cells at the same rate as cancer cells. So hair loss, mouth ulcers, and suppression of red and white blood cells usually occurs. Even the best chemo drugs only kill about 80% of the cancer cells and the rest can live on. If the immune system of the patient gets very damaged by the therapy, then the cancer grows back and takes over. Most cancer patients do not die of their cancer, they die because they get infections and their immune system doesn't work. This traditional strategy has been used for 50 years with marginal success for long term quality and quantity of life.

(to be continued)

EXTRA:

Source 1: The Lancet ONCOLOGY

INSULIN POTENTIATION THERAPY DEFINED

Insulin is responsible for cellular glucose uptake and mitogenic signalling cascades in cancer cells,1 and can promote cell proliferation, survival, invasiveness, angiogenesis, immunomodulation, and chemoresistance. Why, then, would some medical practitioners claim that the use of insulin and glucose can improve the outcomes of patients with cancer and facilitate cancer therapy de-escalation?

IPT: A NEW CONCEPT IN MANAGEMENT OF CHRONIC DEGENERATIVE DISEASE

S G Ayre, D Perez Garcia y Bellon, D Perez Garcia Jr

Source: PUBMED/NIH-National Library of Medicine

"In insulin potentiation therapy the hormone insulin is used as an adjunct in the medical management of the chronic degenerative diseases including malignant neoplasia. In this, the recognized physiological action of insulin--that of increasing cell membrane permeability--is taken advantage of to potentiate the pharmacological actions of medications administered concurrently in the therapy. This potentiation occurs because of the heretofore unrecognized applicability of this membrane permeabilizing effect of insulin to a much wider range of tissues than is classically accepted, and further the observed effect of this permeabilizing phenomenon as it relates to drug molecules, most importantly the antineoplastic agents...."

(continued)

THE IPT EDUCATIONAL MOVEMENT
There's very few clinics around that have been able to figure out this IPT strategy. A lot of doctors who go into integrated medicine have a hard time making it. Our clinic supports the expansion of this protocol to help other clinics understand and promote IPT. We help everyone understand the effective treatment modalities for these various things where you could educate doctors and save them 25 years of R&D. It took me about 25 years of seminars and expanded training and there's still so much to learn! I continue to explore if there's a better way to do what we're doing.

Within the next six months or so, we're putting together a package program where doctors can get a comprehensive course on IPT. I have two new doctors working with me in my clinic and in a matter of three months and I have them up and running. They're able to do what I'm doing with the same kind of success that I have had. This methodology can be duplicated. The overall intention of my program is to provide this for people where it's organized and accessible and so far, we have great success with it.

Our protocol involves taking blood from the patient and sending it to the RGCC laboratory in Greece and they can test to see which therapies will kill the cancer cells the best.. Here, we can be alerted to the weaknesses of the patient's specific cancer cell. The test includes all the major chemo drugs and newer immune drugs and also natural substances like vitamin C, garlic, curcumin, etc. it takes the guess work out of which therapy will be the most effective. It also gives us the answers about how you can get to it, the chemo drugs we need and how you can block glucose getting in. From here, you'll know how you can block or turn on its anti-cancer chromosomes. Now you have a whole bunch of things hitting these cells at the same time.

Patients get IPT once a week. To this is added IV vitamin C, ozone with methylene blue, pulsed magnetic field, hyperbaric oxygen With over 20 different treatments, the cancer cells are now in a panic -- and the cells are now thinking "I can't figure this out, I'm gonna die". I believe this is the winning strategy that outperforms traditional approaches in most cases. I think the best therapy is a combination of these various modalities, which most of them are immune supportive of our own immune system and attack cancer cells.

MORE TRUTHS ABOUT CANCER
You can't kill cancer with just carrot juice or Kelly enzymes for most people. These cancers are super smart. They have the most sophisticated methods of figuring out how to survive in the face of what you're doing. This is one of the big failures of regular chemotherapy-- it's a one trick pony. The oncologist commonly says, “It doesn't matter what you eat, it doesn't matter what your stress level is, it doesn't matter, what vitamins you take—“you just take this chemotherapy and we're going to save you". This has hardly been a winning strategy for most people. We do integrative oncology, which means we take the best of the pharmaceuticals and the best from nature and in combination we get the best results.

# # #

Dr. David Minkoff is an American physician and best selling author. He is the co-founder and medical director of LifeWorks Wellness Center and a regular speaker at numerous conferences on health, wellness, Lyme disease, ozone therapy, alternative cancer treatment, and autoimmune diseases. (see Dr. Minkoff's complete bio)

News Extra:

MEET PRENUVO: ADVANCED FULL BODY MRI FOR CANCER SCREENING & MONITORING

On April 20, NYCRA NEWS conducted a special interview with DR. RAJ ATTARIWALA, Nuclear Medicine Radiologist, PhD Biomedical Engineer and Founding Radiologist of Prenuvo. Known commonly as "Dr. Raj", he shares his commitment to improving on the current state of modalities in cancer diagnostics by offering advancements on the performance, range and design of our current MRI technology. "In simplistic terms, having a full-body access comports to the fact that everything is connected in one way or another. Tumor cells start somewhere, but they can spread almost anywhere they want. If we find a cancer in stage one (which usually means confined to the organ of origin) what happens afterwards is to ask if it is IN FACT confined to that organ, or if it has spread somewhere else. This is called staging." (See full feature)

* Extra: Video interviews with MedTech Reporter Dr. Robert Bard + Prenuvo Founder/CEO Andrew Lacy

A LEGACY OFCANCER THERAPY POTENTIATION
The NY Cancer Resource Alliance is proud to honor the work of Dr. Donato Pérez García - leading global expert in IPT/IPTLD (Insulin Potentiation therapy)- a bioregenerative medical procedure. Dr. Donato has been practicing the IPT protocol since 1983 and is a current and active physician in Tijuana, Mexico. He is Certified in Regenerative Medicine and Stem Cell Therapy. He is also a Member, Advisor and Professor of the Medical College for Regenerative Medicine. He focused his research on the expansion of cancer treatment, arthritic conditions and an array of chronic illnesses since founded by two prior generations of his forefathers in the 50's. See his exclusive interview available only on NYCRA NEWS.

ONCO-IMMUNOLOGY (Originally posted Jun 27, 2019 @ The First Responders Cancer Awareness TV) WESTBURY — NYCRA (NY Cancer Resource Alliance) and the First Responders Cancer Awareness group presents Part 3 of our program: "A REVIEW OF ALL CANCERS". Host "Cousin" Sal Banchitta, ret. FDNY brings you our "Walking Cancer Encyclopedia" - Dr. Jesse Stoff who presents the world of cancer care in a way that's easy-to follow and helps us understand our body's Immune System. Dr. Stoff is a world-renowned speaker and published author about this topic and is one of NYCRA's top clinical advisors and technical authorities in the field of Cancer Solutions. (See full video interview)

BREAST CANCER IN MEN- IT'S REAL!

10/8/2021- SYNDICATED NEWS (Pix-CH11): Breast Cancer Awareness (Presented by: Marvin Scott) Veteran journalist and recipient of 11 prestigious Emmy awards for journalistic achievement, Marvin Scott presents one of the most under-reported cancers in America: MALE BREAST CANCER. In collaboration with the Male Breast Cancer Coalition, Mr. Scott interviews survivors and clinical cancer imaging expert, NYC's own Dr. Robert Bard- who uncovers the scientific analysis and scanning options of this insidious disease that's rising in numbers. Mr. Scott has entrusted the expertise of Dr. Bard on prior health news reports including Melanoma, Skin Cancer and Prostate Cancer. (See Video)

DENSE BREAST NEWS: 2023
Originally published: 1/19-2023- The ARE YOU DENSE ADVOCACY committee continues to recognize the importance of patients receiving their own personal medical information and directs the Food and Drug Administration to ensure that mammography reports and summaries received by patients and their providers include appropriate information about breast density specified by the Secretary, including, at a minimum, the effect of breast density in masking the presence of breast cancer on a mammogram, the qualitative assessment of the provider who interpreted the mammogram, and a reminder to patients that individuals with dense breast tissue should talk with their providers if they have any questions or concerns about their summary. From a prior report (3/28/2019) the Department of Health and Human Services, the FDA announced changes to the MQSA (Mammography Quality Standards Act) to include reporting of dense breast tissue to the patient- by and large, thanks to the Are You Dense Advocacy, Inc. (see complete feature)